Tanshinone IIA induces apoptosis via inhibition of Wnt/β-catenin/MGMT signaling in AtT-20 cells

A strategy to suppress the expression of the DNA repair enzyme O(6)-methylguanine-DNA methyltransferase (MGMT) by inhibition of Wnt/β-catenin signaling may be useful as a novel treatment for pituitary adenoma. Previous studies have reported that Tanshinone IIA (TSA), a major quinone compound isolate...

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Publicado no:Mol Med Rep
Main Authors: Li, Zong-Yang, Huang, Guo-Dong, Chen, Lei, Zhang, Ce, Chen, Bao-Dong, Li, Qing-Zhong, Wang, Xiang, Zhang, Xie-Jun, Li, Wei-Ping
Formato: Artigo
Idioma:Inglês
Publicado em: D.A. Spandidos 2017
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Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5865768/
https://ncbi.nlm.nih.gov/pubmed/28849207
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3892/mmr.2017.7325
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