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Click chemistry enables preclinical evaluation of targeted epigenetic therapies
The success of new therapies hinges on our ability to understand their molecular and cellular mechanisms of action. We modified BET bromodomain inhibitors, an epigenetic-based therapy, to create functionally conserved compounds that are amenable to click chemistry and can be used as molecular probes...
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| 發表在: | Science |
|---|---|
| Main Authors: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
| 格式: | Artigo |
| 語言: | Inglês |
| 出版: |
2017
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| 主題: | |
| 在線閱讀: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5865750/ https://ncbi.nlm.nih.gov/pubmed/28619718 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.aal2066 |
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