The circadian clock regulates cisplatin-induced toxicity and tumor regression in melanoma mouse and human models

Cisplatin is one of the most commonly used chemotherapeutic drugs; however, toxicity and tumor resistance limit its use. Studies using murine models and human subjects have shown that the time of day of cisplatin treatment influences renal and blood toxicities. We hypothesized that the mechanisms re...

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Detalhes bibliográficos
Publicado no:Oncotarget
Main Authors: Dakup, Panshak P., Porter, Kenneth I., Little, Alexander A., Gajula, Rajendra P., Zhang, Hui, Skornyakov, Elena, Kemp, Michael G., Van Dongen, Hans P.A, Gaddameedhi, Shobhan
Formato: Artigo
Idioma:Inglês
Publicado em: Impact Journals LLC 2018
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5865687/
https://ncbi.nlm.nih.gov/pubmed/29581861
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.24539
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