The circadian clock regulates cisplatin-induced toxicity and tumor regression in melanoma mouse and human models

Cisplatin is one of the most commonly used chemotherapeutic drugs; however, toxicity and tumor resistance limit its use. Studies using murine models and human subjects have shown that the time of day of cisplatin treatment influences renal and blood toxicities. We hypothesized that the mechanisms re...

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Veröffentlicht in:Oncotarget
Hauptverfasser: Dakup, Panshak P., Porter, Kenneth I., Little, Alexander A., Gajula, Rajendra P., Zhang, Hui, Skornyakov, Elena, Kemp, Michael G., Van Dongen, Hans P.A, Gaddameedhi, Shobhan
Format: Artigo
Sprache:Inglês
Veröffentlicht: Impact Journals LLC 2018
Schlagworte:
Research Paper
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5865687/
https://ncbi.nlm.nih.gov/pubmed/29581861
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.24539
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