A Method for Characterising Human Intervertebral Disc Glycosaminoglycan Disaccharides using Liquid Chromatography-Mass Spectrometry with Multiple Reaction Monitoring

Intervertebral disc (IVD) degeneration results in the depletion of proteoglycans and glycosaminoglycans (GAGs), which can lead to structural and mechanical loss of IVD function, ingrowth of nociceptive nerve fbres and eventually discogenic pain. Specifc GAG types as well as their disaccharide patern...

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Publicado en:Eur Cell Mater
Main Authors: Liu, X., Krishnamoorthy, D., Lin, L., Xue, P., Zhang, F., Chi, L., Linhardt, R.J., Iatridis, J.C.
Formato: Artigo
Idioma:Inglês
Publicado: 2018
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC5865475/
https://ncbi.nlm.nih.gov/pubmed/29469163
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.22203/eCM.v035a09
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