Induction of Interleukin 10 by Borrelia burgdorferi Is Regulated by the Action of CD14-Dependent p38 Mitogen-Activated Protein Kinase and cAMP-Mediated Chromatin Remodeling

Host genotype influences the severity of murine Lyme borreliosis, caused by the spirochetal bacterium Borrelia burgdorferi. C57BL/6 (B6) mice develop mild Lyme arthritis, whereas C3H/HeN (C3H) mice develop severe Lyme arthritis. Differential expression of interleukin 10 (IL-10) has long been associa...

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Detalhes bibliográficos
Publicado no:Infect Immun
Main Authors: Sahay, Bikash, Bashant, Kathleen, Nelson, Nicole L. J., Patsey, Rebeca L., Gadila, Shiva Kumar, Boohaker, Rebecca, Verma, Ashutosh, Strle, Klemen, Sellati, Timothy J.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2018
Assuntos:
Cellular Microbiology: Pathogen-Host Cell Molecular Interactions
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5865024/
https://ncbi.nlm.nih.gov/pubmed/29311239
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/IAI.00781-17
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