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Controlled branched-chain amino acids auxotrophy in Listeria monocytogenes allows isoleucine to serve as a host signal and virulence effector

Listeria monocytogenes (Lm) is a saprophyte and intracellular pathogen. Transition to the pathogenic state relies on sensing of host-derived metabolites, yet it remains unclear how these are recognized and how they mediate virulence gene regulation. We previously found that low availability of isole...

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Detalhes bibliográficos
Publicado no:PLoS Genet
Main Authors: Brenner, Moran, Lobel, Lior, Borovok, Ilya, Sigal, Nadejda, Herskovits, Anat A.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2018
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5864092/
https://ncbi.nlm.nih.gov/pubmed/29529043
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1007283
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