Argonaute2 and LaminB modulate gene expression by controlling chromatin topology

Drosophila Argonaute2 (AGO2) has been shown to regulate expression of certain loci in an RNA interference (RNAi)-independent manner, but its genome-wide function on chromatin remains unknown. Here, we identified the nuclear scaffolding protein LaminB as a novel interactor of AGO2. When either AGO2 o...

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Udgivet i:PLoS Genet
Main Authors: Nazer, Ezequiel, Dale, Ryan K., Chinen, Madoka, Radmanesh, Behram, Lei, Elissa P.
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2018
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5864089/
https://ncbi.nlm.nih.gov/pubmed/29529026
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1007276
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