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A role for 2-Cys peroxiredoxins in facilitating cytosolic protein thiol oxidation

Hydrogen peroxide (H(2)O(2)) acts as a signaling messenger by triggering the reversible oxidation of redox-regulated proteins. It remains unclear how proteins can be oxidized by signaling levels of H(2)O(2) in the presence of peroxiredoxins, which are highly efficient peroxide scavengers. Here we sh...

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Veröffentlicht in:Nat Chem Biol
Hauptverfasser: Stöcker, Sarah, Maurer, Michael, Ruppert, Thomas, Dick, Tobias P
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2017
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Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5863949/
https://ncbi.nlm.nih.gov/pubmed/29251718
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nchembio.2536
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