Atovaquone Impairs Growth of Aspergillus and Fusarium Keratitis Isolates by Modulating Mitochondrial Function and Zinc Homeostasis

PURPOSE: Aspergillus and Fusarium molds cause blinding corneal infections as a consequence of ocular trauma and in association with contact lens wear. As these fungi require zinc for fungal growth, we examined the effect of atovaquone, a ubiquinone analog that disrupts zinc homeostasis, on fungal gr...

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Publicado en:Invest Ophthalmol Vis Sci
Autores principales: Clark, Heather L., Minns, Martin S., Sun, Yan, de Jesus, Tristan, Ghannoum, Mahmoud G., Pearlman, Eric
Formato: Artigo
Lenguaje:Inglês
Publicado: The Association for Research in Vision and Ophthalmology 2018
Materias:
Immunology and Microbiology
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC5863689/
https://ncbi.nlm.nih.gov/pubmed/29625485
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1167/iovs.17-22585
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