Combined sublethal irradiation and agonist anti-CD40 enhance donor T cell accumulation and control of autochthonous murine pancreatic tumors

Tumor-reactive T lymphocytes can promote the regression of established tumors. However, their efficacy is often limited by immunosuppressive mechanisms that block T cell accumulation or function. ACT provides the opportunity to ameliorate immune suppression prior to transfer of tumor-reactive T cell...

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Veröffentlicht in:Cancer Immunol Immunother
Hauptverfasser: Ward-Kavanagh, Lindsay K., Kokolus, Kathleen M., Cooper, Timothy K., Lukacher, Aron E., Schell, Todd D.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Springer Berlin Heidelberg 2018
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Original Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5862761/
https://ncbi.nlm.nih.gov/pubmed/29332158
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00262-018-2115-2
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