A randomised double blind placebo controlled phase 2 trial of adjunctive aspirin for tuberculous meningitis in HIV-uninfected adults

Adjunctive dexamethasone reduces mortality from tuberculous meningitis (TBM) but not disability, which is associated with brain infarction. We hypothesised that aspirin prevents TBM-related brain infarction through its anti-thrombotic, anti-inflammatory, and pro-resolution properties. We conducted a...

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Detalhes bibliográficos
Publicado no:eLife
Main Authors: Mai, Nguyen TH, Dobbs, Nicholas, Phu, Nguyen Hoan, Colas, Romain A, Thao, Le TP, Thuong, Nguyen TT, Nghia, Ho DT, Hanh, Nguyen HH, Hang, Nguyen T, Heemskerk, A Dorothee, Day, Jeremy N, Ly, Lucy, Thu, Do DA, Merson, Laura, Kestelyn, Evelyne, Wolbers, Marcel, Geskus, Ronald, Summers, David, Chau, Nguyen VV, Dalli, Jesmond, Thwaites, Guy E
Formato: Artigo
Idioma:Inglês
Publicado em: eLife Sciences Publications, Ltd 2018
Assuntos:
Microbiology and Infectious Disease
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5862527/
https://ncbi.nlm.nih.gov/pubmed/29482717
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.33478
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