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Reexamining cancer metabolism: lactate production for carcinogenesis could be the purpose and explanation of the Warburg Effect

Herein, we use lessons learned in exercise physiology and metabolism to propose that augmented lactate production (‘lactagenesis’), initiated by gene mutations, is the reason and purpose of the Warburg Effect and that dysregulated lactate metabolism and signaling are the key elements in carcinogenes...

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Bibliografiske detaljer
Udgivet i:Carcinogenesis
Main Authors: San-Millán, Iñigo, Brooks, George A.
Format: Artigo
Sprog:Inglês
Udgivet: Oxford University Press 2017
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5862360/
https://ncbi.nlm.nih.gov/pubmed/27993896
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/carcin/bgw127
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