Induction of non-apoptotic programmed cell death by oncogenic RAS in human epithelial cells and its suppression by MYC overexpression

Oncogenic mutations of RAS genes, found in about 30% of human cancers, are considered to play important roles in cancer development. However, oncogenic RAS can also induce senescence in mouse and human normal fibroblasts. In some cell lines, oncogenic RAS has been reported to induce non-apoptotic pr...

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Veröffentlicht in:Carcinogenesis
Hauptverfasser: Dendo, Kasumi, Yugawa, Takashi, Nakahara, Tomomi, Ohno, Shin-ichi, Goshima, Naoki, Arakawa, Hirofumi, Kiyono, Tohru
Format: Artigo
Sprache:Inglês
Veröffentlicht: Oxford University Press 2018
Schlagworte:
Carcinogenesis
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5862353/
https://ncbi.nlm.nih.gov/pubmed/29106503
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/carcin/bgx124
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