Sulforaphane suppresses PRMT5/MEP50 function in epidermal squamous cell carcinoma leading to reduced tumor formation

Protein arginine methyltransferase 5 (PRMT5) cooperates with methylosome protein 50 (MEP50) to arginine methylate histone H3 and H4 to silence gene expression, and increased PRMT5 activity is associated with enhanced cancer cell survival. We have studied the role of PRMT5 and MEP50 in epidermal squa...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Carcinogenesis
Prif Awduron: Saha, Kamalika, Fisher, Matthew L, Adhikary, Gautam, Grun, Daniel, Eckert, Richard L
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Oxford University Press 2017
Pynciau:
Original Manuscript
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC5862259/
https://ncbi.nlm.nih.gov/pubmed/28854561
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/carcin/bgx044
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