Sulforaphane suppresses PRMT5/MEP50 function in epidermal squamous cell carcinoma leading to reduced tumor formation

Protein arginine methyltransferase 5 (PRMT5) cooperates with methylosome protein 50 (MEP50) to arginine methylate histone H3 and H4 to silence gene expression, and increased PRMT5 activity is associated with enhanced cancer cell survival. We have studied the role of PRMT5 and MEP50 in epidermal squa...

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Dades bibliogràfiques
Publicat a:Carcinogenesis
Autors principals: Saha, Kamalika, Fisher, Matthew L, Adhikary, Gautam, Grun, Daniel, Eckert, Richard L
Format: Artigo
Idioma:Inglês
Publicat: Oxford University Press 2017
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Original Manuscript
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5862259/
https://ncbi.nlm.nih.gov/pubmed/28854561
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/carcin/bgx044
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