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Sulforaphane suppresses PRMT5/MEP50 function in epidermal squamous cell carcinoma leading to reduced tumor formation

Protein arginine methyltransferase 5 (PRMT5) cooperates with methylosome protein 50 (MEP50) to arginine methylate histone H3 and H4 to silence gene expression, and increased PRMT5 activity is associated with enhanced cancer cell survival. We have studied the role of PRMT5 and MEP50 in epidermal squa...

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Bibliografski detalji
Izdano u:Carcinogenesis
Glavni autori: Saha, Kamalika, Fisher, Matthew L, Adhikary, Gautam, Grun, Daniel, Eckert, Richard L
Format: Artigo
Jezik:Inglês
Izdano: Oxford University Press 2017
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5862259/
https://ncbi.nlm.nih.gov/pubmed/28854561
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/carcin/bgx044
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