Jab1/Csn5-thioredoxin signaling in relapsed acute monocytic leukemia under oxidative stress

PURPOSE: High levels of ROS and ineffective antioxidant systems contribute to oxidative stress, which affects the function of hematopoietic cells in acute myeloid leukemia (AML); however, the mechanisms by which ROS lead to malignant transformation in relapsed AML-M5 are not completely understood. W...

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Dettagli Bibliografici
Pubblicato in:Clin Cancer Res
Autori principali: Zhou, Fuling, Pan, Yunbao, Wei, Yongchang, Zhang, Ronghua, Bai, Gaigai, Shen, Qiuju, Meng, Shan, Le, Xiao-Feng, Andreeff, Michael, Claret, Francois X.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2017
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5861712/
https://ncbi.nlm.nih.gov/pubmed/28270496
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-16-2426
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