MiR-16 regulates the pro-tumorigenic potential of lung fibroblasts through the inhibition of HGF production in an FGFR-1- and MEK1-dependent manner

BACKGROUND: Fibroblasts are crucial mediators of tumor-stroma cross-talk through synthesis and remodeling of the extracellular matrix and production of multiple soluble factors. Nonetheless, little is still known about specific determinants of fibroblast pro-tumorigenic activity in lung cancer. Here...

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Detalhes bibliográficos
Publicado no:J Hematol Oncol
Main Authors: Andriani, Francesca, Majorini, Maria Teresa, Mano, Miguel, Landoni, Elena, Miceli, Rosalba, Facchinetti, Federica, Mensah, Mavis, Fontanella, Enrico, Dugo, Matteo, Giacca, Mauro, Pastorino, Ugo, Sozzi, Gabriella, Delia, Domenico, Roz, Luca, Lecis, Daniele
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2018
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5861674/
https://ncbi.nlm.nih.gov/pubmed/29558956
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13045-018-0594-4
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