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Polyubiquitination Is Required for US11-dependent Movement of MHC Class I Heavy Chain from Endoplasmic Reticulum into Cytosol

The human cytomegalovirus protein US11 induces the dislocation of MHC class I heavy chains from the endoplasmic reticulum (ER) into the cytosol for degradation by the proteasome. With the use of a fractionated, permeabilized cell system, we find that US11 activity is needed only in the cell membrane...

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Detalhes bibliográficos
Main Authors: Shamu, Caroline E., Flierman, Dennis, Ploegh, Hidde L., Rapoport, Tom A., Chau, Vincent
Formato: Artigo
Idioma:Inglês
Publicado em: The American Society for Cell Biology 2001
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC58612/
https://ncbi.nlm.nih.gov/pubmed/11514634
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