Identification of di-substituted ureas that prevent growth of trypanosomes through inhibition of translation initiation

Some 1,3-diarylureas and 1-((1,4-trans)−4-aryloxycyclohexyl)−3-arylureas (cHAUs) activate heme-regulated kinase causing protein synthesis inhibition via phosphorylation of the eukaryotic translation initiation factor 2 (eIF2) in mammalian cancer cells. To evaluate if these agents have potential to i...

Täydet tiedot

Tallennettuna:
Bibliografiset tiedot
Julkaisussa:Sci Rep
Päätekijät: Machado, Fabricio Castro, Franco, Caio Haddad, dos Santos Neto, Jose Vitorino, Dias-Teixeira, Karina Luiza, Moraes, Carolina Borsoi, Lopes, Ulisses Gazos, Aktas, Bertal Huseyin, Schenkman, Sergio
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: Nature Publishing Group UK 2018
Aiheet:
Article
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC5861040/
https://ncbi.nlm.nih.gov/pubmed/29559670
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-018-23259-9
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