Skeletal Muscle–Specific Deletion of MKP-1 Reveals a p38 MAPK/JNK/Akt Signaling Node That Regulates Obesity-Induced Insulin Resistance

Stress responses promote obesity and insulin resistance, in part, by activating the stress-responsive mitogen-activated protein kinases (MAPKs), p38 MAPK, and c-Jun NH(2)-terminal kinase (JNK). Stress also induces expression of MAPK phosphatase-1 (MKP-1), which inactivates both JNK and p38 MAPK. How...

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Bibliographic Details
Published in:Diabetes
Main Authors: Lawan, Ahmed, Min, Kisuk, Zhang, Lei, Canfran-Duque, Alberto, Jurczak, Michael J., Camporez, Joao Paulo G., Nie, Yaohui, Gavin, Timothy P., Shulman, Gerald I., Fernandez-Hernando, Carlos, Bennett, Anton M.
Format: Artigo
Language:Inglês
Published: American Diabetes Association 2018
Subjects:
Signal Transduction
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5860856/
https://ncbi.nlm.nih.gov/pubmed/29317435
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2337/db17-0826
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