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Exercise Prevents Maternal High-Fat Diet–Induced Hypermethylation of the Pgc-1α Gene and Age-Dependent Metabolic Dysfunction in the Offspring

Abnormal conditions during early development adversely affect later health. We investigated whether maternal exercise could protect offspring from adverse effects of a maternal high-fat diet (HFD) with a focus on the metabolic outcomes and epigenetic regulation of the metabolic master regulator, per...

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Detalhes bibliográficos
Publicado no:Diabetes
Main Authors: Laker, Rhianna C., Lillard, Travis S., Okutsu, Mitsuharu, Zhang, Mei, Hoehn, Kyle L., Connelly, Jessica J., Yan, Zhen
Formato: Artigo
Idioma:Inglês
Publicado em: American Diabetes Association 2014
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5860829/
https://ncbi.nlm.nih.gov/pubmed/24430439
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2337/db13-1614
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