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SUMO E3 ligase Mms21 prevents spontaneous DNA damage induced genome rearrangements
Mms21, a subunit of the Smc5/6 complex, possesses an E3 ligase activity for the Small Ubiquitin-like MOdifier (SUMO). Here we show that the mms21-CH mutation, which inactivates Mms21 ligase activity, causes increased accumulation of gross chromosomal rearrangements (GCRs) selected in the dGCR assay....
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| Publicado no: | PLoS Genet |
|---|---|
| Main Authors: | , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Public Library of Science
2018
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5860785/ https://ncbi.nlm.nih.gov/pubmed/29505562 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1007250 |
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