A Zoom-Focus algorithm (ZFA) to locate the optimal testing region for rare variant association tests

MOTIVATION: Increasing amounts of whole exome or genome sequencing data present the challenge of analysing rare variants with extremely small minor allele frequencies. Various statistical tests have been proposed, which are specifically configured to increase power for rare variants by conducting th...

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Veröffentlicht in:Bioinformatics
Hauptverfasser: Wang, Maggie Haitian, Weng, Haoyi, Sun, Rui, Lee, Jack, Wu, William Ka Kei, Chong, Ka Chun, Zee, Benny Chung-Ying
Format: Artigo
Sprache:Inglês
Veröffentlicht: Oxford University Press 2017
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Original Papers
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5860107/
https://ncbi.nlm.nih.gov/pubmed/28334355
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/bioinformatics/btx130
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