A Zoom-Focus algorithm (ZFA) to locate the optimal testing region for rare variant association tests

MOTIVATION: Increasing amounts of whole exome or genome sequencing data present the challenge of analysing rare variants with extremely small minor allele frequencies. Various statistical tests have been proposed, which are specifically configured to increase power for rare variants by conducting th...

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Dettagli Bibliografici
Pubblicato in:Bioinformatics
Autori principali: Wang, Maggie Haitian, Weng, Haoyi, Sun, Rui, Lee, Jack, Wu, William Ka Kei, Chong, Ka Chun, Zee, Benny Chung-Ying
Natura: Artigo
Lingua:Inglês
Pubblicazione: Oxford University Press 2017
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Original Papers
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5860107/
https://ncbi.nlm.nih.gov/pubmed/28334355
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/bioinformatics/btx130
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