Understanding human genetic factors influencing primaquine safety and efficacy to guide primaquine roll-out in a pre-elimination setting in southern Africa

BACKGROUND: Primaquine (PQ) is recommended as an addition to standard malaria treatments in pre-elimination settings due to its pronounced activity against mature Plasmodium falciparum gametocytes, the parasite stage responsible for onward transmission to mosquitoes. However, PQ may trigger haemolys...

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Detalhes bibliográficos
Publicado no:Malar J
Main Authors: Awandu, Shehu S., Raman, Jaishree, Makhanthisa, Takalani I., Kruger, Philip, Frean, John, Bousema, Teun, Niemand, Jandeli, Birkholtz, Lyn-Marie
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2018
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5859786/
https://ncbi.nlm.nih.gov/pubmed/29558929
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12936-018-2271-z
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