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Nuclear Relocalization of the Pre-mRNA Splicing Factor PSF during Apoptosis Involves Hyperphosphorylation, Masking of Antigenic Epitopes, and Changes in Protein Interactions

The spatial nuclear organization of regulatory proteins often reflects their functional state. PSF, a factor essential for pre-mRNA splicing, is visualized by the B92 mAb as discrete nuclear foci, which disappeared during apoptosis. Because this mode of cell death entails protein degradation, it was...

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Bibliografiske detaljer
Main Authors: Shav-Tal, Yaron, Cohen, Michal, Lapter, Smadar, Dye, Billy, Patton, James G., Vandekerckhove, Joel, Zipori, Dov
Format: Artigo
Sprog:Inglês
Udgivet: The American Society for Cell Biology 2001
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC58597/
https://ncbi.nlm.nih.gov/pubmed/11514619
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