S-Nitroso-N-acetyl-L-cysteine ethyl ester (SNACET) and N-acetyl-L-cysteine ethyl ester (NACET)–Cysteine-based drug candidates with unique pharmacological profiles for oral use as NO, H(2)S and GSH suppliers and as antioxidants: Results and overview

S-Nitrosothiols or thionitrites with the general formula RSNO are formally composed of the nitrosyl cation (NO(+)) and a thiolate (RS(−)), the base of the corresponding acids RSH. The smallest S-nitrosothiol is HSNO and derives from hydrogen sulfide (HSH, H(2)S). The most common physiological S-nitr...

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Detalhes bibliográficos
Publicado no:J Pharm Anal
Main Authors: Tsikas, Dimitrios, Schwedhelm, Kathrin S., Surdacki, Andrzej, Giustarini, Daniela, Rossi, Ranieri, Kukoc-Modun, Lea, Kedia, George, Ückert, Stefan
Formato: Artigo
Idioma:Inglês
Publicado em: Xi'an Jiaotong University 2018
Assuntos:
Review Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5859134/
https://ncbi.nlm.nih.gov/pubmed/29568662
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jpha.2017.12.003
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