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E. coli Nissle 1917-Derived Minicells for Targeted Delivery of Chemotherapeutic Drug to Hypoxic Regions for Cancer Therapy

Purpose: Systemic administration of free chemotherapeutic drugs leads to severe toxic effects, and physiological characteristics of solid tumors restrain the drugs from reaching the hypoxic regions. E. coli Nissle 1917 (EcN) has been known to penetrate the barrier and proliferate in the interface be...

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Detalhes bibliográficos
Publicado no:Theranostics
Main Authors: Zhang, Yunlei, Ji, Wei, He, Lian, Chen, Yiyan, Ding, Xuezhi, Sun, Yunjun, Hu, Shengbiao, Yang, Huijun, Huang, Weitao, Zhang, Youming, Liu, Fei, Xia, Liqiu
Formato: Artigo
Idioma:Inglês
Publicado em: Ivyspring International Publisher 2018
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5858176/
https://ncbi.nlm.nih.gov/pubmed/29556350
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7150/thno.21575
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