Mitochondria-targeted spin-labelled luminescent iridium anticancer complexes

Mitochondria generate energy but malfunction in many cancer cells, hence targeting mitochondrial metabolism is a promising approach for cancer therapy. Here we have designed cyclometallated iridium(iii) complexes, containing one TEMPO (2,2,6,6-tetramethylpiperidine-1-oxyl) spin label [C(43)H(43)N(6)...

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Bibliographic Details
Published in:Chem Sci
Main Authors: Venkatesh, V., Berrocal-Martin, Raul, Wedge, Christopher J., Romero-Canelón, Isolda, Sanchez-Cano, Carlos, Song, Ji-Inn, Coverdale, James P. C., Zhang, Pingyu, Clarkson, Guy J., Habtemariam, Abraha, Magennis, Steven W., Deeth, Robert J., Sadler, Peter J.
Format: Artigo
Language:Inglês
Published: Royal Society of Chemistry 2017
Subjects:
Chemistry
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5857930/
https://ncbi.nlm.nih.gov/pubmed/29568475
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/c7sc03216a
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