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Quinine blocks specific gap junction channel subtypes

We demonstrate that the antimalarial drug quinine specifically reduces currents through gap junctions formed by some connexins (Cx) in transfected mammalian cells, but does not affect other gap junction types. Quinine blocked Cx36 and Cx50 junctional currents in a reversible and concentration-depend...

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Bibliografski detalji
Glavni autori: Srinivas, Miduturu, Hopperstad, Matthew G., Spray, David C.
Format: Artigo
Jezik:Inglês
Izdano: The National Academy of Sciences 2001
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC58578/
https://ncbi.nlm.nih.gov/pubmed/11535816
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.191206198
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