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Quinine blocks specific gap junction channel subtypes

We demonstrate that the antimalarial drug quinine specifically reduces currents through gap junctions formed by some connexins (Cx) in transfected mammalian cells, but does not affect other gap junction types. Quinine blocked Cx36 and Cx50 junctional currents in a reversible and concentration-depend...

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Detalles Bibliográficos
Main Authors: Srinivas, Miduturu, Hopperstad, Matthew G., Spray, David C.
Formato: Artigo
Idioma:Inglês
Publicado: The National Academy of Sciences 2001
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC58578/
https://ncbi.nlm.nih.gov/pubmed/11535816
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.191206198
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