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Quinine blocks specific gap junction channel subtypes

We demonstrate that the antimalarial drug quinine specifically reduces currents through gap junctions formed by some connexins (Cx) in transfected mammalian cells, but does not affect other gap junction types. Quinine blocked Cx36 and Cx50 junctional currents in a reversible and concentration-depend...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: Srinivas, Miduturu, Hopperstad, Matthew G., Spray, David C.
Format: Artigo
Sprache:Inglês
Veröffentlicht: The National Academy of Sciences 2001
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC58578/
https://ncbi.nlm.nih.gov/pubmed/11535816
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.191206198
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