Combined Treatment With Dichloroacetic Acid and Pyruvate Reduces Hippocampal Neuronal Death After Transient Cerebral Ischemia

Transient cerebral ischemia (TCI) occurs when blood flow to the brain is ceased or dramatically reduced. TCI causes energy depletion and oxidative stress, which leads to neuronal death and cognitive impairment. Dichloroacetic acid (DCA) acts as an inhibitor of pyruvate dehydrogenase kinase (PDK). Ad...

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Detalhes bibliográficos
Publicado no:Front Neurol
Main Authors: Hong, Dae Ki, Kho, A Ra, Choi, Bo Young, Lee, Song Hee, Jeong, Jeong Hyun, Lee, Sang Hwon, Park, Kyoung-Ha, Park, Jae-Bong, Suh, Sang Won
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2018
Assuntos:
Neuroscience
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5857568/
https://ncbi.nlm.nih.gov/pubmed/29593636
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fneur.2018.00137
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