Dicer-2-Dependent Generation of Viral DNA from Defective Genomes of RNA Viruses Modulates Antiviral Immunity in Insects

The RNAi pathway confers antiviral immunity in insects. Virus-specific siRNA responses are amplified via the reverse transcription of viral RNA to viral DNA (vDNA). The nature, biogenesis, and regulation of vDNA are unclear. We find that vDNA produced during RNA virus infection of Drosophila and mos...

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Detalhes bibliográficos
Publicado no:Cell Host Microbe
Main Authors: Poirier, Enzo Z., Goic, Bertsy, Tomé-Poderti, Lorena, Frangeul, Lionel, Boussier, Jérémy, Gausson, Valérie, Blanc, Hervé, Vallet, Thomas, Loyd, Hyelee, Levi, Laura I., Lanciano, Sophie, Baron, Chloé, Merkling, Sarah H., Lambrechts, Louis, Mirouze, Marie, Carpenter, Susan, Vignuzzi, Marco, Saleh, Maria-Carla
Formato: Artigo
Idioma:Inglês
Publicado em: Cell Press 2018
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5857290/
https://ncbi.nlm.nih.gov/pubmed/29503180
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.chom.2018.02.001
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