Dicer-2-Dependent Generation of Viral DNA from Defective Genomes of RNA Viruses Modulates Antiviral Immunity in Insects

The RNAi pathway confers antiviral immunity in insects. Virus-specific siRNA responses are amplified via the reverse transcription of viral RNA to viral DNA (vDNA). The nature, biogenesis, and regulation of vDNA are unclear. We find that vDNA produced during RNA virus infection of Drosophila and mos...

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Bibliografiska uppgifter
I publikationen:Cell Host Microbe
Huvudupphovsmän: Poirier, Enzo Z., Goic, Bertsy, Tomé-Poderti, Lorena, Frangeul, Lionel, Boussier, Jérémy, Gausson, Valérie, Blanc, Hervé, Vallet, Thomas, Loyd, Hyelee, Levi, Laura I., Lanciano, Sophie, Baron, Chloé, Merkling, Sarah H., Lambrechts, Louis, Mirouze, Marie, Carpenter, Susan, Vignuzzi, Marco, Saleh, Maria-Carla
Materialtyp: Artigo
Språk:Inglês
Publicerad: Cell Press 2018
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Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC5857290/
https://ncbi.nlm.nih.gov/pubmed/29503180
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.chom.2018.02.001
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