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A randomised, double-blind, placebo-controlled phase 1 study of the safety, tolerability and pharmacodynamics of volixibat in overweight and obese but otherwise healthy adults: implications for treatment of non-alcoholic steatohepatitis

BACKGROUND: Accumulation of toxic free cholesterol in hepatocytes may cause hepatic inflammation and fibrosis. Volixibat inhibits bile acid reuptake via the apical sodium bile acid transporter located on the luminal surface of the ileum. The resulting increase in bile acid synthesis from cholesterol...

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書目詳細資料
發表在:BMC Pharmacol Toxicol
Main Authors: Palmer, Melissa, Jennings, Lee, Silberg, Debra G., Bliss, Caleb, Martin, Patrick
格式: Artigo
語言:Inglês
出版: BioMed Central 2018
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC5857122/
https://ncbi.nlm.nih.gov/pubmed/29548345
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s40360-018-0200-y
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