Identification of sarilumab pharmacodynamic and predictive markers in patients with inadequate response to TNF inhibition: a biomarker substudy of the phase 3 TARGET study

INTRODUCTION: Interleukin-6 (IL-6) orchestrates formation of an inflammatory pannus, leading to joint damage in rheumatoid arthritis (RA). Sarilumab is a human monoclonal antibody blocking the IL-6Rα. In TARGET (NCT01709578), a phase 3 study in adults with moderate-to-severe RA and inadequate respon...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:RMD Open
Prif Awduron: Gabay, Cem, Msihid, Jérôme, Zilberstein, Moshe, Paccard, Caroline, Lin, Yong, Graham, Neil M H, Boyapati, Anita
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: BMJ Publishing Group 2018
Pynciau:
Rheumatoid Arthritis
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC5856917/
https://ncbi.nlm.nih.gov/pubmed/29556418
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1136/rmdopen-2017-000607
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