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Cellular Pharmacokinetic Model-based Analysis of Genistein, Glyceollin and MK-571 Effects on 5 (and 6)-Carboxy-2′,7′-Dichloroflourescein Disposition in Caco-2 Cells
Pharmacokinetic modeling was used to describe 5 (and 6)-Carboxy-2′,7′-Dichloroflourescein (CDF) disposition in Caco-2 cells following CDF or CDFDA (CDF diacetate) dosing. CDF transcellular flux was modeled by simple passive diffusion. CDFDA-dosing models were based on simultaneous fitting of CDF lev...
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| Udgivet i: | J Pharm Sci |
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| Main Authors: | , , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
2017
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5856607/ https://ncbi.nlm.nih.gov/pubmed/29247742 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.xphs.2017.12.004 |
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