Lentivirus-mediated overexpression of OTULIN ameliorates microglia activation and neuroinflammation by depressing the activation of the NF-κB signaling pathway in cerebral ischemia/reperfusion rats

BACKGROUND: Ischemic stroke-induced neuroinflammation is mainly mediated by microglial cells. The nuclear factor kappa B (NF-κB) pathway is the key transcriptional pathway that initiates inflammatory responses following cerebral ischemia. OTULIN, a critical negative regulator of the NF-κΒ signaling...

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Опубликовано в: :J Neuroinflammation
Главные авторы: Xu, Hongbei, Qin, Wenyi, Hu, Xiao, Mu, Song, Zhu, Jun, Lu, Wenhao, Luo, Yong
Формат: Artigo
Язык:Inglês
Опубликовано: BioMed Central 2018
Предметы:
Research
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC5856386/
https://ncbi.nlm.nih.gov/pubmed/29544517
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12974-018-1117-5
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