Comparison of whole-genome bisulfite sequencing library preparation strategies identifies sources of biases affecting DNA methylation data

BACKGROUND: Whole-genome bisulfite sequencing (WGBS) is becoming an increasingly accessible technique, used widely for both fundamental and disease-oriented research. Library preparation methods benefit from a variety of available kits, polymerases and bisulfite conversion protocols. Although some s...

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Foilsithe in:Genome Biol
Main Authors: Olova, Nelly, Krueger, Felix, Andrews, Simon, Oxley, David, Berrens, Rebecca V., Branco, Miguel R., Reik, Wolf
Formáid: Artigo
Teanga:Inglês
Foilsithe: BioMed Central 2018
Ábhair:
Research
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5856372/
https://ncbi.nlm.nih.gov/pubmed/29544553
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13059-018-1408-2
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