Llwytho...
Biophysical characterization of hit compounds for mechanism-based enzyme activation
Across all families of enzymes, only a dozen or so distinct classes of non-natural small molecule activators have been characterized, with only four known modes of activation among them. All of these modes of activation rely on naturally evolved binding sites that trigger global conformational chang...
Wedi'i Gadw mewn:
| Cyhoeddwyd yn: | PLoS One |
|---|---|
| Prif Awduron: | , , , |
| Fformat: | Artigo |
| Iaith: | Inglês |
| Cyhoeddwyd: |
Public Library of Science
2018
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| Pynciau: | |
| Mynediad Ar-lein: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5856274/ https://ncbi.nlm.nih.gov/pubmed/29547630 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0194175 |
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