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High Throughput NPY-Venus and Serotonin Secretion Assays for Regulated Exocytosis in Neuroendocrine Cells

Here we describe two assays to measure dense core vesicle (DCV) exocytosis-mediated cargo secretion in neuroendocrine cells. To conduct siRNA screens for novel genes in regulated DCV exocytosis, we developed a plate reader-based secretion assay using DCV cargo, NPY-Venus, and an orthogonal (3)H-sero...

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Bibliografiske detaljer
Udgivet i:Bio Protoc
Main Authors: Zhang, Xingmin Aaron, Martin, Thomas F.J.
Format: Artigo
Sprog:Inglês
Udgivet: Bio-Protocol 2018
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5856254/
https://ncbi.nlm.nih.gov/pubmed/29552592
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.21769/BioProtoc.2680
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