The Effect of Treatment with Guanfacine, an Alpha2 Adrenergic Agonist, on Dopaminergic Tone in Tobacco Smokers: An [(11)C]FLB457 PET Study

Guanfacine, a noradrenergic alpha2a agonist, reduced tobacco smoking in a 4-week trial and in animal models has been shown to reduce cortical dopamine release, which is critically involved in the reinforcing effect of tobacco smoking. We measured amphetamine-induced extrastriatal dopamine release be...

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Detalhes bibliográficos
Publicado no:Neuropsychopharmacology
Main Authors: Sandiego, Christine M, Matuskey, David, Lavery, Meaghan, McGovern, Erin, Huang, Yiyun, Nabulsi, Nabeel, Ropchan, Jim, Picciotto, Marina R, Morris, Evan D, McKee, Sherry A, Cosgrove, Kelly P
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2018
Assuntos:
Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5854798/
https://ncbi.nlm.nih.gov/pubmed/28944773
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/npp.2017.223
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