TNF-α blockade impairs in vitro tuberculous granuloma formation and down modulate Th1, Th17 and Treg cytokines

Tuberculosis (TB) is a granulomatous disease that has affected humanity for thousands of years. The production of cytokines, such as IFN-γ and TNF-α, is fundamental in the formation and maintenance of granulomas and in the control of the disease. Recently, the introduction of TNF-α-blocking monoclon...

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Publicat a:PLoS One
Autors principals: da Silva, Djalma A. Alves, da Silva, Marcos V., Barros, Cleyson C. Oliveira, Alexandre, Patrícia B. Dias, Timóteo, Rodolfo P., Catarino, Jonatas S., Sales-Campos, Helioswilton, Machado, Juliana R., Rodrigues, Denise B. R., Oliveira, Carlo J., Rodrigues, Virmondes
Format: Artigo
Idioma:Inglês
Publicat: Public Library of Science 2018
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5854376/
https://ncbi.nlm.nih.gov/pubmed/29543912
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0194430
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