Immunoglobulin A Protease Variants Facilitate Intracellular Survival in Epithelial Cells By Nontypeable Haemophilus influenzae That Persist in the Human Respiratory Tract in Chronic Obstructive Pulmonary Disease

BACKGROUND: Nontypeable Haemophilus influenzae (NTHi) persists in the airways in chronic obstructive pulmonary disease (COPD). NTHi expresses 4 immunoglobulin (Ig)A protease variants (A1, A2, B1, B2) with distinct cleavage specificities for human IgA1. Little is known about the different roles of Ig...

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Detalhes bibliográficos
Publicado no:J Infect Dis
Main Authors: Murphy, Timothy F, Kirkham, Charmaine, Gallo, Mary C, Yang, Yang, Wilding, Gregory E, Pettigrew, Melinda M
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2017
Assuntos:
Major Articles and Brief Reports
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5853902/
https://ncbi.nlm.nih.gov/pubmed/28968876
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/infdis/jix471
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