Characterization of TTN Novex Splicing Variants across Species and the Role of RBM20 in Novex-Specific Exon Splicing

Titin (TTN) is a major disease-causing gene in cardiac muscle. Titin (TTN) contains 363 exons in human encoding various sizes of TTN protein due to alternative splicing regulated mainly by RNA binding motif 20 (RBM20). Three isoforms of TTN protein are produced by mutually exclusive exons 45 (Novex...

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Publicat a:Genes (Basel)
Autors principals: Chen, Zhilong, Song, Jiangping, Chen, Liang, Zhu, Chaoqun, Cai, Hanfang, Sun, Mingming, Stern, Allysa, Mozdziak, Paul, Ge, Ying, Means, Warrie J., Guo, Wei
Format: Artigo
Idioma:Inglês
Publicat: MDPI 2018
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5852582/
https://ncbi.nlm.nih.gov/pubmed/29438341
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/genes9020086
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