OxLDL-derived lysophosphatidic acid promotes the progression of aortic valve stenosis through a LPAR1-RhoA–NF-κB pathway

AIMS: Oxidatively modified lipoproteins may promote the development/progression of calcific aortic valve stenosis (CAVS). Oxidative transformation of low-density lipoprotein (OxLDL) generates lysophosphatidic acid (LPA), a lipid mediator that accumulates in mineralized aortic valves. LPA activates a...

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Dades bibliogràfiques
Publicat a:Cardiovasc Res
Autors principals: Nsaibia, Mohamed Jalloul, Boulanger, Marie-Chloé, Bouchareb, Rihab, Mkannez, Ghada, Le Quang, Khai, Hadji, Fayez, Argaud, Deborah, Dahou, Abdellaziz, Bossé, Yohan, Koschinsky, Marlys L., Pibarot, Philippe, Arsenault, Benoit J., Marette, André, Mathieu, Patrick
Format: Artigo
Idioma:Inglês
Publicat: Oxford University Press 2017
Matèries:
Original Articles
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5852522/
https://ncbi.nlm.nih.gov/pubmed/28472283
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/cvr/cvx089
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