Activation of Myofibroblast TRPA1 by Steroids and Pirfenidone Ameliorates Fibrosis in Experimental Crohn's Disease

BACKGROUND & AIMS: The transient receptor potential ankyrin 1 (TRPA1) channel is highly expressed in the intestinal lamina propria, but its contribution to gut physiology/pathophysiology is unclear. Here, we evaluated the function of myofibroblast TRPA1 channels in intestinal remodeling. METHODS...

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Detalhes bibliográficos
Publicado no:Cell Mol Gastroenterol Hepatol
Main Authors: Kurahara, Lin Hai, Hiraishi, Keizo, Hu, Yaopeng, Koga, Kaori, Onitsuka, Miki, Doi, Mayumi, Aoyagi, Kunihiko, Takedatsu, Hidetoshi, Kojima, Daibo, Fujihara, Yoshitaka, Jian, Yuwen, Inoue, Ryuji
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier 2017
Assuntos:
Original Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5852292/
https://ncbi.nlm.nih.gov/pubmed/29552620
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jcmgh.2017.12.005
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