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Many Routes to an Antibody Heavy-Chain CDR3: Necessary, Yet Insufficient, for Specific Binding

Because of its great potential for diversity, the immunoglobulin heavy-chain complementarity-determining region 3 (HCDR3) is taken as an antibody molecule’s most important component in conferring binding activity and specificity. For this reason, HCDR3s have been used as unique identifiers to invest...

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Detalhes bibliográficos
Publicado no:Front Immunol
Main Authors: D’Angelo, Sara, Ferrara, Fortunato, Naranjo, Leslie, Erasmus, M. Frank, Hraber, Peter, Bradbury, Andrew R. M.
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2018
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5852061/
https://ncbi.nlm.nih.gov/pubmed/29568296
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2018.00395
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