Down syndrome associated childhood myeloid leukemia with yet unreported acquired chromosomal abnormalities and a new potential adverse marker: dup(1)(q25q44)

BACKGROUND: Children with constitutional trisomy 21, i.e. Down syndrome (DS, OMIM #190685) have a 10 to 20-fold increased risk for a hematopoietic malignancy. They may suffer from acute lymphoblastic leukemia or acute myeloid leukemia (AML). AML referred to as myeloid leukemia of Down syndrome (ML-D...

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Veröffentlicht in:Mol Cytogenet
Hauptverfasser: Moassass, Faten, Wafa, Abdulsamad, Liehr, Thomas, Al-Ablog, Ayman, AL Achkar, Walid
Format: Artigo
Sprache:Inglês
Veröffentlicht: BioMed Central 2018
Schlagworte:
Case Report
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5851247/
https://ncbi.nlm.nih.gov/pubmed/29563973
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13039-018-0370-8
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