A single dose of anti-miR-122, RG-101, in CHC patients results in NK cell normalization with no effect on HCV-specific CD8+ T cell function

MicroRNA-122 (miR-122) is an important host factor for the hepatitis C virus. Treatment with RG-101, a GalNAc conjugated anti-miR-122 oligonucleotide, resulted in a significant viral load reduction in patients with chronic hepatitis C (CHC) infection. Here, we analyzed the effects of RG-101 therapy...

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Detalhes bibliográficos
Publicado no:Hepatology
Main Authors: Stelma, Femke, van der Ree, Meike H, Sinnige, Marjan J, Brown, Anthony, Swadling, Leo, de Vree, J Marleen L, Willemse, Sophie B, van der Valk, Marc, Grint, Paul, Neben, Steven, Klenerman, Paul, Barnes, Eleanor, Kootstra, Neeltje A, Reesink, Hendrik W
Formato: Artigo
Idioma:Inglês
Publicado em: 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5850982/
https://ncbi.nlm.nih.gov/pubmed/28295463
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/hep.29148
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