Codon-Resolution Analysis Reveals a Direct and Context-Dependent Impact of Individual Synonymous Mutations on mRNA Level

Codon usage bias (CUB) refers to the observation that synonymous codons are not used equally frequently in a genome. CUB is stronger in more highly expressed genes, a phenomenon commonly explained by stronger natural selection on translational accuracy and/or efficiency among these genes. Neverthele...

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Bibliografiske detaljer
Udgivet i:Mol Biol Evol
Main Authors: Chen, Siyu, Li, Ke, Cao, Wenqing, Wang, Jia, Zhao, Tong, Huan, Qing, Yang, Yu-Fei, Wu, Shaohuan, Qian, Wenfeng
Format: Artigo
Sprog:Inglês
Udgivet: Oxford University Press 2017
Fag:
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Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5850819/
https://ncbi.nlm.nih.gov/pubmed/28961875
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/molbev/msx229
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