Dissecting HIV Virulence: Heritability of Setpoint Viral Load, CD4+ T-Cell Decline, and Per-Parasite Pathogenicity

Pathogen strains may differ in virulence because they attain different loads in their hosts, or because they induce different disease-causing mechanisms independent of their load. In evolutionary ecology, the latter is referred to as “per-parasite pathogenicity”. Using viral load and CD4+ T-cell mea...

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Publicado en:Mol Biol Evol
Autores principales: Bertels, Frederic, Marzel, Alex, Leventhal, Gabriel, Mitov, Venelin, Fellay, Jacques, Günthard, Huldrych F, Böni, Jürg, Yerly, Sabine, Klimkait, Thomas, Aubert, Vincent, Battegay, Manuel, Rauch, Andri, Cavassini, Matthias, Calmy, Alexandra, Bernasconi, Enos, Schmid, Patrick, Scherrer, Alexandra U, Müller, Viktor, Bonhoeffer, Sebastian, Kouyos, Roger, Regoes, Roland R
Formato: Artigo
Lenguaje:Inglês
Publicado: Oxford University Press 2018
Materias:
Discoveries
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC5850767/
https://ncbi.nlm.nih.gov/pubmed/29029206
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/molbev/msx246
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