Pediatric Dilated Cardiomyopathy‐Associated LRRC10 (Leucine‐Rich Repeat–Containing 10) Variant Reveals LRRC10 as an Auxiliary Subunit of Cardiac L‐Type Ca(2+) Channels

BACKGROUND: Genetic causes of dilated cardiomyopathy (DCM) are incompletely understood. LRRC10 (leucine‐rich repeat–containing 10) is a cardiac‐specific protein of unknown function. Heterozygous mutations in LRRC10 have been suggested to cause DCM, and deletion of Lrrc10 in mice results in DCM. METH...

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Bibliographic Details
Published in:J Am Heart Assoc
Main Authors: Woon, Marites T., Long, Pamela A., Reilly, Louise, Evans, Jared M., Keefe, Alexis M., Lea, Martin R., Beglinger, Carl J., Balijepalli, Ravi C., Lee, Youngsook, Olson, Timothy M., Kamp, Timothy J.
Format: Artigo
Language:Inglês
Published: John Wiley and Sons Inc. 2018
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Original Research
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5850229/
https://ncbi.nlm.nih.gov/pubmed/29431102
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/JAHA.117.006428
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