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Intra-individual purifying selection on mitochondrial DNA variants during human oogenesis
STUDY QUESTION: Does selection for mtDNA mutations occur in human oocytes? SUMMARY ANSWER: We provide statistical evidence in favor of the existence of purifying selection for mtDNA mutations in human oocytes acting between the expulsion of the first and second polar bodies (PBs). WHAT IS KNOWN ALRE...
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Publicado no: | Hum Reprod |
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Main Authors: | , , , , , , , |
Formato: | Artigo |
Idioma: | Inglês |
Publicado em: |
Oxford University Press
2017
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Assuntos: | |
Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5850138/ https://ncbi.nlm.nih.gov/pubmed/28333293 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/humrep/dex051 |
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