Intra-individual purifying selection on mitochondrial DNA variants during human oogenesis

STUDY QUESTION: Does selection for mtDNA mutations occur in human oocytes? SUMMARY ANSWER: We provide statistical evidence in favor of the existence of purifying selection for mtDNA mutations in human oocytes acting between the expulsion of the first and second polar bodies (PBs). WHAT IS KNOWN ALRE...

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Detalhes bibliográficos
Publicado no:Hum Reprod
Main Authors: De Fanti, Sara, Vicario, Saverio, Lang, Martin, Simone, Domenico, Magli, Cristina, Luiselli, Donata, Gianaroli, Luca, Romeo, Giovanni
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2017
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Original Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5850138/
https://ncbi.nlm.nih.gov/pubmed/28333293
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/humrep/dex051
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